Cetylpyridinium Chloride | C21H38ClN - PubChem S. Sowmiah, J. M. S. S. Esperana, L. P. N. Rebelo and C. A. M. Afonso, 2. Your predictions need to be accurate to 1 pH unit. Antimicrobial Activity, Biocompatibility and Anti-inflammatory Properties of Cetylpyridinium Chloride-based Mouthwash Containing Sodium Fluoride and Xylitol: An In Vitro Study. The first step in any equilibrium problem is to determine a reaction that describes the system. A: Given: Use an appropriate reaction to justify your answer. [12], CPC mouthwashes inactivate viruses, including Covid viruses, by breaking their lipid envelope. This is the same answer we got using either the Ka or Kb expressions. This leads to $[\ce{H3O+}]=4.85*10^{-5}\to\mathrm{pK_a}=4.314$. &\ce{Approximation} &&0.189 &&0.147 &&\ce{x}\nonumber C5H5NH + + H2O ==> C5H5N + H + Now we need the Ka for C5H5NH + which I looked up and found to be 5.6x10-6 Ka = [C5H5N] [H +] / [C5H5NH +] As a base it could undergo the following reaction (note that this is the Kb reaction). Though one study seems to indicate cetylpyridinium chloride does not cause brown tooth stains,[4] at least one mouthwash containing CPC as an active ingredient bears the warning label "In some cases, antimicrobial rinses may cause surface staining to teeth,"[5] following a failed class-action lawsuit brought by customers whose teeth were stained. Calculate the pH of a 10 M C5H5NHCl (aq) (pyridine chloride salt of pyridine) at 25 C. It is an antiseptic that kills bacteria and other microorganisms. Calculate the pH at 25 C of a 0.41M solution of pyridinium chloride (C;H;NHC1). Asking for help, clarification, or responding to other answers. Arzneimittelforschung. Epub 2007 Aug 11. (PDF) 1-Dodecylpyridinium Chloride Monohydrate - ResearchGate Additionally, gas-phase basicity (GB) and proton affinity (PA) values were computed for systems studied. Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. However, there is something very important to realize about this system. Note that pyridine (C,H,N) is a weak base with a p K, of 8.77. An official website of the United States government. \end{array} Did the drapes in old theatres actually say "ASBESTOS" on them? We found that the treatment of these equilibrium mixtures with strong acylating agents such as trifluoroacetic anhydride, trichloroacetyl chloride, or ethyl oxalyl chloride produces 3-acyl-1,4-dihydropyridines 2 .
ka of pyridinium chloride